Dataset Information

Coffee consumption and liver-related hospitalizations and deaths in the ARIC study.

ABSTRACT:

Background/objectives

Coffee consumption has been found to be associated with reduced risk of chronic conditions such as liver disease. However, less is known about the association between coffee and liver-related hospitalizations and deaths.

Subjects/methods

We conducted a prospective analysis on 14,208 participants aged 45-64 years from the Atherosclerosis Risk in Communities (ARIC) study. Coffee consumption (cups/day) was assessed using food frequency questionnaires at visit 1 (1987-89) and visit 3 (1993-95). Liver-related hospitalizations were defined as a hospitalization with any International Classification of Diseases, Ninth Revision (ICD-9) code related to liver disease identified through cohort surveillance. Liver-related death was defined as any death with a liver disease ICD-9 code listed anywhere on the death certificate form.

Results

There were 833 incident cases of liver-related hospitalizations over a median follow-up of 24 years and 152 liver-related deaths over a median follow-up of 25 years. Participants who were in the highest category of coffee consumption (≥ 3 cups/day) were more likely to be men, whites, current smokers, and current alcohol drinkers. In our fully adjusted model, consuming ≥ 3 cups/day of coffee was significantly associated with a reduced risk of liver-related hospitalizations compared with never drinkers (hazard ratio: 0.79, 95% CI: 0.63-0.99). There were no significant associations between coffee consumption and liver-related deaths after adjusting for covariates.

Conclusions

Coffee drinkers may be at lower risk for liver-related hospitalizations. This supports current evidence that low and moderate levels of coffee may be protective to the liver.

SUBMITTER: Hu EA

PROVIDER: S-EPMC6474824 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Publications

Coffee consumption and liver-related hospitalizations and deaths in the ARIC study.

Hu Emily A EA Lazo Mariana M Selvin Elizabeth E Hamilton James P JP Grams Morgan E ME Steffen Lyn M LM Coresh Josef J Rebholz Casey M CM

European journal of clinical nutrition 20181019 8

<h4>Background/objectives</h4>Coffee consumption has been found to be associated with reduced risk of chronic conditions such as liver disease. However, less is known about the association between coffee and liver-related hospitalizations and deaths.<h4>Subjects/methods</h4>We conducted a prospective analysis on 14,208 participants aged 45-64 years from the Atherosclerosis Risk in Communities (ARIC) study. Coffee consumption (cups/day) was assessed using food frequency questionnaires at visit 1 ...[more]

PMID: 30341433

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Dataset Information

Coffee consumption and liver-related hospitalizations and deaths in the ARIC study.

Background/objectives

Subjects/methods

Results

Conclusions

Publications

Coffee consumption and liver-related hospitalizations and deaths in the ARIC study.

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