Interaction of RNA viruses of the natural virome with the African malaria vector, Anopheles coluzzii.

ABSTRACT: Mosquitoes are colonized by a little-studied natural virome. Like the bacterial microbiome, the virome also probably influences the biology and immunity of mosquito vector populations, but tractable experimental models are lacking. We recently discovered two novel viruses in the virome of wild Anopheles and in colonies of the malaria vector Anopheles coluzzii: Anopheles C virus and Anopheles cypovirus. Here, we describe biological interactions between these two viruses and An. coluzzii mosquitoes. Viral abundance varies reproducibly during mosquito development. DNA forms of these viruses were not detected, and thus viral persistence is likely based on vertical transmission of RNA genomes. At least Anopheles C virus is vertically transmitted by an intraembryonic route. Relative abundance of

SUBMITTER: Nanfack-Minkeu F 

PROVIDER: S-EPMC6474895 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature