Predictive Value of ¹⁸F-Sodium Fluoride Positron Emission Tomography in Detecting High-Risk Coronary Artery Disease in Combination With Computed Tomography.

ABSTRACT: Background Application of ¹⁸F-sodium fluoride (¹⁸F-NaF) positron emission tomography ( PET ) to coronary artery disease has attracted interest. We investigated the utility of ¹⁸F-NaF uptake for predicting coronary events and evaluated the combined use of coronary computed tomography (CT) angiography ( CCTA ) and ¹⁸F-NaF PET /CT in coronary artery disease risk assessment. Methods and Results This study included patients with ≥1 coronary atherosclerotic lesion detected on CCTA who underwent ¹⁸F-NaF PET / CT . High-risk plaque on CCTA was defined as plaque with low density (<30 Hounsfield units) and high remodeling index (>1.1). Focal ¹⁸F-NaF uptake in each lesion was quantified using the maximum tissue:background ratio ( TBR <

SUBMITTER: Kitagawa T 

PROVIDER: S-EPMC6474946 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature