Optimal Application of Fractional Flow Reserve to Assess Serial Coronary Artery Disease: A 3D-Printed Experimental Study With Clinical Validation.

ABSTRACT: Background Assessing the physiological significance of stenoses with coexistent serial disease is prone to error. We aimed to use 3-dimensional-printing to characterize serial stenosis interplay and to derive and validate a mathematical solution to predict true stenosis significance in serial disease. Methods and Results Fifty-two 3-dimensional-printed serial disease phantoms were physiologically assessed by pressure-wire pullback (Δ FFR _app) and compared with phantoms with the stenosis in isolation (Δ FFR _true). Mathematical models to minimize error in predicting FFR _true, the FFR in the vessel where the stenosis is present in isolation, were subsequently developed using 32 phantoms and validated in another 20 and also a clinical cohort of 30 patients with

SUBMITTER: Modi BN 

PROVIDER: S-EPMC6474982 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature