Ontology highlight
ABSTRACT:
SUBMITTER: Vallabh SM
PROVIDER: S-EPMC6475435 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Vallabh Sonia M SM Nobuhara Chloe K CK Llorens Franc F Zerr Inga I Parchi Piero P Capellari Sabina S Kuhn Eric E Klickstein Jacob J Safar Jiri G JG Nery Flavia C FC Swoboda Kathryn J KJ Geschwind Michael D MD Zetterberg Henrik H Arnold Steven E SE Minikel Eric Vallabh EV Schreiber Stuart L SL
Proceedings of the National Academy of Sciences of the United States of America 20190401 16
Reduction of native prion protein (PrP) levels in the brain is an attractive strategy for the treatment or prevention of human prion disease. Clinical development of any PrP-reducing therapeutic will require an appropriate pharmacodynamic biomarker: a practical and robust method for quantifying PrP, and reliably demonstrating its reduction in the central nervous system (CNS) of a living patient. Here we evaluate the potential of ELISA-based quantification of human PrP in human cerebrospinal flui ...[more]