Concise Total Synthesis of Herqulines B and C.

ABSTRACT: A simple total synthesis of herqulines B and C is reported, modeled on the reductive biosynthesis reported previously by other researchers. Commencing from tyrosine, these alkaloids were fashioned through a dimerization, macrocyclization, and four consecutive reductions. Emerging from these studies are strategic insights on the synthesis of these strained alkaloids, as well as mild conditions for the exhaustive reduction of diketopiperizines.

SUBMITTER: He C 

PROVIDER: S-EPMC6475496 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature