Decolonization to Reduce Postdischarge Infection Risk among MRSA Carriers.

ABSTRACT:

Background

Hospitalized patients who are colonized with methicillin-resistant Staphylococcus aureus (MRSA) are at high risk for infection after discharge.

Methods

We conducted a multicenter, randomized, controlled trial of postdischarge hygiene education, as compared with education plus decolonization, in patients colonized with MRSA (carriers). Decolonization involved chlorhexidine mouthwash, baths or showers with chlorhexidine, and nasal mupirocin for 5 days twice per month for 6 months. Participants were followed for 1 year. The primary outcome was MRSA infection as defined according to Centers for Disease Control and Prevention (CDC) criteria. Secondary outcomes included MRSA infection determined on the basis of clinical judgment, infection from any cause, and infection-

SUBMITTER: Huang SS 

PROVIDER: S-EPMC6475519 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature