Body composition and atrial fibrillation: a Mendelian randomization study.

ABSTRACT:

Aims

Increases in fat-free mass and fat mass have been associated with higher risk of atrial fibrillation (AF) in observational studies. It is not known whether these associations reflect independent causal processes. Our aim was to evaluate independent causal roles of fat-free mass and fat mass on AF.

Methods and results

We conducted a large observational study to estimate the associations between fat-free mass and fat mass on incident AF in the UK Biobank (N = 487 404, N events = 10 365). Genome-wide association analysis was performed to obtain genetic instruments for Mendelian randomization (MR). We evaluated the causal effects of fat-free mass and fat mass on AF with two-sample method by using genetic associations from AFGen consortium as outcome. Finally, we evaluated i

SUBMITTER: Tikkanen E 

PROVIDER: S-EPMC6475522 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature