Scan-Time Corrections for 80-100-min Standardizetd Uptake Volume Ratios to Measure the ¹⁸F-AV-1451 Tracer for Tau Imaging.

ABSTRACT: The ¹⁸F-AV-1451 PET tracer binds to tau, an Alzheimer's disease biomarker. The standardized uptake value ratio (SUVR) 80-100 min window is widely used to quantify tau binding, although ¹⁸F-AV-1451 continues increasing relative to a reference region in regions with tau deposition. Left uncorrected, acquisition time inaccuracies can lead to errors from -4% to 6% in 20-min SUVR measurements in subjects with Alzheimer's disease. In 40 subjects with scans from 75-115 min following ¹⁸F-AV-1451 injection, we created 20-min reconstructions (4×5 min) of start-times ranging from 75-85 min, as proxies of offset scans and calculated the mean in regions of interest (ROIs). We developed a segmented least squares (SLS) method to obtain error-minimizing weighting coefficie

SUBMITTER: He M 

PROVIDER: S-EPMC6475617 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature