Cellular and Molecular Responses Unique to Major Injury Are Dispensable for Planarian Regeneration.

ABSTRACT: The fundamental requirements for regeneration are poorly understood. Planarians can robustly regenerate all tissues after injury, involving stem cells, positional information, and a set of cellular and molecular responses collectively called the "missing tissue" or "regenerative" response. follistatin, which encodes an extracellular Activin inhibitor, is required for the missing tissue response after head amputation and for subsequent regeneration. We found that follistatin is required for the missing tissue response regardless of the wound context, but causes regeneration failure only after head amputation. This head regeneration failure involves follistatin-mediated regulation of Wnt signaling at wounds and is not a consequence of a diminished missing tissue response. All tested contexts

SUBMITTER: Tewari AG 

PROVIDER: S-EPMC6475882 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature