MRI guided stereotactic radiotherapy for locally advanced pancreatic cancer.

ABSTRACT:

Objective:

We want to explore the safety and technical feasibility of MRI-guided stereotactic radiotherapy for locally advanced pancreatic cancer.

Methods:

A custom-made abdominal corset was manufactured to reduce breathing induced tumour motion. Delineation of the tumour and organs at risk (OARs) was performed on CT and multiparametric MRI. Tumour motion was quantified with cine MRI. After treatment planning, the static dose distribution was convolved with the cine MRI-based motion trajectory to simulate the delivered dose to the tumour and OARs. Stereotactic body radiation therapy (SBRT) was carried out up to a dose of 24 G in three fractions in 1 week.

Results:

From July 2013 to January 2016, 20 patients were included. Tumours and OARs were clearly visible with con

SUBMITTER: Heerkens HD 

PROVIDER: S-EPMC6475956 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature