Metabolomics Analysis in Serum from Patients with Colorectal Polyp and Colorectal Cancer by ¹H-NMR Spectrometry.

ABSTRACT: Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide. Colorectal adenomatous polyps are at high risk for the development of CRC. In this report, we described the metabolic changes in the sera from patients with colorectal polyps and CRC by using the NMR-based metabolomics. 110 serum samples were collected from patients and healthy controls, including 40 CRC patients, 32 colorectal polyp patients, and 38 healthy controls. The metabolic profiles and differential metabolites of sera were analyzed by multivariate statistical analysis (MSA), including principal component analysis (PCA), partial least squares discriminant analysis (PLS-DA), and orthogonal partial least squares discriminant analysis (OPLS-DA) methods. A total of 23 differential metabolites were i

SUBMITTER: Gu J 

PROVIDER: S-EPMC6476004 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature