Neuregulin-1 Fosters Supportive Interactions between Microglia and Neural Stem/Progenitor Cells.

ABSTRACT: Microglia play diverse roles in homeostasis and pathology of the central nervous system (CNS). Their response to injury or insult is critical for initiating neuroinflammation and tissue damage as well as resolution of inflammation and wound healing. Changes to the microenvironment of microglia appear to be a key determinant of their phenotype and their role in the endogenous repair process in the injured or diseased CNS. Our recent findings have identified a positive role for neuregulin-1 (Nrg-1) in regulating immune response in spinal cord injury and focal demyelinating lesions. We show that increasing the tissue availability of Nrg-1 after injury can promote endogenous repair by modulating neuroinflammation. In the present study, we sought to elucidate the specific role of Nrg-1 in regul

SUBMITTER: Shahriary GM 

PROVIDER: S-EPMC6476022 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature