Mesenchymal Progenitors Derived from Different Locations in Long Bones Display Diverse Characteristics.

ABSTRACT: Mesenchymal progenitors within bone marrow have multiple differentiation potential and play an essential role in the maintenance of adult skeleton homeostasis. Mesenchymal progenitors located in bone regions other than the bone marrow also display bone-forming properties. However, owing to the differences in each distinct microenvironment, the mesenchymal characteristics of skeletal progenitor cells within different regions of long bones may show some differences. In order to clearly elucidate these differences, we performed a comparative study on mesenchymal progenitors from different regions of long bones. Here, we isolated mesenchymal progenitors from the periosteum, endosteum, and bone marrow of rat long bones. The three groups exhibited similar cellular morphologies and expressed the

SUBMITTER: Lu W 

PROVIDER: S-EPMC6476036 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature