GlSir2.1 of Giardia lamblia is a NAD⁺-dependent cytoplasmic deacetylase.

ABSTRACT: The sirtuins are a group of well-conserved proteins widely distributed across all domains of life. These proteins are clustered in the class III of histone deacetylases and are distinctly characterized by their dependence upon NAD⁺ to carry out the deacetylation of lysine residues in histone proteins (H3 and H4) and non-histones such as the transcription factor p53. The requirement of NAD⁺ for sirtuin activity makes this group of proteins metabolic sensors, which are favored during caloric stress. Currently, it is known that these proteins are involved in numerous cellular processes that are fundamental for the proper functioning of cells, including control of the cell cycle and cellular survival. In spite of the importance of sirtuins in cell functions, the role that

SUBMITTER: Herrera T EA 

PROVIDER: S-EPMC6476225 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature