Chemical Profiling and Biological Screening of Some River Nile Derived-Microorganisms.

ABSTRACT:

Aims

Chemical and biological studies of the River Nile derived-microorganisms are limited. Hence, this work was carried out to screen the River Nile habitat. Identification of the isolated organisms, chemical profiling of their ethyl acetate extracts as well as screening of their antimicrobial, antileishmanial, antitrypanosomal, and antimalarial activities were investigated.

Methods

Identification of the microbial isolates were carried out using bacterial 16S rRNA and fungal 18S rRNA gene sequencing. Chemical profiling of the EtOAc extracts using LC-HRESIMS spectroscopy was carried out. The in vitro antimicrobial screening using the modified version of the CLSI method, antileishmanial and antitrypanosomal activities were screened using Leishmania donovani proma

SUBMITTER: Lotfy MM 

PROVIDER: S-EPMC6476301 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature