Obesity, risk of biochemical recurrence, and prostate-specific antigen doubling time after radical prostatectomy: results from the SEARCH database.

ABSTRACT:

Objectives

To examine the association between body mass index (BMI) and aggressive biochemical recurrence (BCR) using the Shared Equal Access Regional Cancer Hospital (SEARCH) database.

Material and methods

We identified 4123 men with complete data treated by radical prostatectomy between 1988 and 2015. We tested the association between BMI and BCR using Cox models, and among men with BCR, prostate-specific antigen doubling time (PSADT) was compared across BMI categories using linear regression. Models were adjusted for age, race, prostate-specific antigen, biopsy Gleason score, clinical stage, year and surgical centre.

Results

Overall, 922 men (22%) were of normal weight (BMI <25 kg/m² ), 1863 (45%) were overweight (BMI 25-29.9 kg/m² ), 968 (24%

SUBMITTER: Freedland SJ 

PROVIDER: S-EPMC6476692 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature