Variability of Betweenness Centrality and Its Effect on Identifying Essential Genes.

ABSTRACT: This paper begins to build a theoretical framework that would enable the pharmaceutical industry to use network complexity measures as a way to identify drug targets. The variability of a betweenness measure for a network node is examined through different methods of network perturbation. Our results indicate a robustness of betweenness centrality in the identification of target genes.

SUBMITTER: Duron C 

PROVIDER: S-EPMC6476710 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature