Identification of epistasis loci underlying rice flowering time by controlling population stratification and polygenic effect.

ABSTRACT: Flowering time is an important agronomic trait, attributed by multiple genes, gene-gene interactions and environmental factors. Population stratification and polygenic effects might confound genetic effects of the causal loci underlying this complex trait. We proposed a two-step approach for detecting epistasis interactions underlying rice flowering time by accounting population structure and polygenic effects. Simulation studies showed that the approach used in this study performs better than classical and PC-linear approaches in terms of powers and false discovery rates in the case of population stratification and polygenic effects. Whole genome epistasis analyses identified 589 putative genetic interactions for flowering time. Eighteen of these interactions are located within 10 kilobas

SUBMITTER: Ahsan A 

PROVIDER: S-EPMC6476725 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature