Combined detection of serum autoantibodies as diagnostic biomarkers in esophagogastric junction adenocarcinoma.

ABSTRACT:

Background

We previously found that autoantibodies against a panel of six tumor-associated antigens (p53, NY-ESO-1, MMP-7, Hsp70, PRDX6 and Bmi-1) may aid in early detection of esophageal squamous cell carcinoma. Here we aimed to evaluate the diagnostic value of this autoantibody panel in esophagogastric junction adenocarcinoma (EJA) patients.

Methods

Serum autoantibody levels were measured by enzyme-linked immunosorbent assay in a training cohort and a validation cohort. We used receiver-operating characteristics (ROC) to calculate diagnostic accuracy.

Results

We recruited 169 normal controls and 122 EJA patients to the training cohort, and 80 normal controls and 70 EJA patients to the validation cohort. Detection of the autoantibody panel demonstrated an area under

SUBMITTER: Xu YW 

PROVIDER: S-EPMC6476828 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature