Wnt Signaling Is a Major Determinant of Neuroblastoma Cell Lineages.

ABSTRACT: The neural crest (NC), which has been referred to as the fourth germ layer, comprises a multipotent cell population which will specify diverse cells and tissues, including craniofacial cartilage and bones, melanocytes, the adrenal medulla and the peripheral nervous system. These cell fates are known to be determined by gene regulatory networks (GRNs) acting at various stages of NC development, such as induction, specification, and migration. Although transcription factor hierarchies and some of their interplay with morphogenetic signaling pathways have been characterized, the full complexity of activities required for regulated development remains uncharted. Deregulation of these pathways may contribute to tumorigenesis, as in the case of neuroblastoma, a frequently lethal embryonic cancer

SUBMITTER: Szemes M 

PROVIDER: S-EPMC6476918 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature