Exercise Overrides Blunted Hypoxic Ventilatory Response in Prematurely Born Men.

ABSTRACT:

Purpose

Pre-term birth provokes life-long anatomical and functional respiratory system sequelae. Although blunted hypoxic ventilatory response (HVR) is consistently observed in pre-term infants, it remains unclear if it persists with aging and, moreover, if it influences hypoxic exercise capacity. In addition, it remains unresolved whether the previously observed prematurity-related alterations in redox balance could contribute to HVR modulation.

Methods

Twenty-one prematurely born adult males (gestational age = 29 ± 4 weeks], and 14 age matched controls born at full term (gestational age = 39 ± 2 weeks) underwent three tests in a randomized manner: (1) hypoxia chemo-sensitivity test to determine the resting and exercise poikilocapnic HVR and a graded exercise

SUBMITTER: Debevec T 

PROVIDER: S-EPMC6476987 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature