Concise Review: Update on Retinal Pigment Epithelium Transplantation for Age-Related Macular Degeneration.

ABSTRACT: Retinal cell therapy can have the objectives of rescue (i.e., modulation of metabolic abnormalities primarily for sight preservation) as well as replacement (i.e., replace cells lost due to injury or disease for sight restoration as well as preservation). The first clinical trials of retinal pigment epithelium (RPE) transplantation for vision-threatening complications of age-related macular degeneration (AMD) have begun with some preliminary signs of success (e.g., improvement in vision in some patients, anatomic evidence of transplant-host integration with some evidence of host photoreceptor recovery, long-term survival of autologous induced pluripotent stem cell-derived RPE transplants without immune suppression) as well as limitations (e.g., limited RPE suspension survival in the AMD ey

SUBMITTER: Zarbin M 

PROVIDER: S-EPMC6477002 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature