Amlodipine alters hemorheological parameters: Increased efficacy at the cost of edema?

ABSTRACT:

Background

Despite several decades of use of calcium channel blockers, the side effect of edema persists as a class effect, and its mechanism is unresolved. Amlodipine has effects on hemorheology (HR), and its hemodilutory property may partly contribute to its antihypertensive action. This aspect is not well studied, and the literature is sparse in this regard.

Objective

This experiment was planned to determine effect of a single-dose administration of amlodipine on HR parameters in normal human volunteers.

Methods and results

Amlodipine (5 mg) or S (-) amlodipine (2.5 mg) was administered to 27 normal human volunteers. Whole-blood viscosity (WBV) at different shear rates, plasma viscosity (PV), red cell rigidity (RCR), red cell aggregation (RCA), hematocrit (Hct), pl

SUBMITTER: Ravindra RP 

PROVIDER: S-EPMC6477139 | biostudies-literature | 2019 Jan - Feb

REPOSITORIES: biostudies-literature