Sodium MRI with 3D-cones as a measure of tumour cellularity in high grade serous ovarian cancer.

ABSTRACT: The aim of this study was to assess the feasibility of rapid sodium MRI (²³Na-MRI) for the imaging of peritoneal cancer deposits in high grade serous ovarian cancer (HGSOC) and to evaluate the relationship of ²³Na-MRI with tumour cellularity. ²³Na-MRI was performed at 3 T on twelve HGSOC patients using a 3D-cones acquisition technique. Tumour biopsies specimens were collected after imaging and cellularity was measured from histology. Total ²³Na-MRI scan time for each patient was approximately 11 min. At an isotropic resolution of 5.6 mm, signal-to-noise ratios (SNRs) of 82.2 ± 15.3 and 15.1 ± 7.1 (mean ± standard deviation) were achieved for imaging of tumour tissue sodium concentration (TSC) and intracellular weighted sodium concentration (IWS)

SUBMITTER: Deen SS 

PROVIDER: S-EPMC6477161 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature