Sodium MRI with 3D-cones as a measure of tumour cellularity in high grade serous ovarian cancer.

ABSTRACT: The aim of this study was to assess the feasibility of rapid sodium MRI (23Na-MRI) for the imaging of peritoneal cancer deposits in high grade serous ovarian cancer (HGSOC) and to evaluate the relationship of 23Na-MRI with tumour cellularity. 23Na-MRI was performed at 3?T on twelve HGSOC patients using a 3D-cones acquisition technique. Tumour biopsies specimens were collected after imaging and cellularity was measured from histology. Total 23Na-MRI scan time for each patient was approximately 11?min. At an isotropic resolution of 5.6?mm, signal-to-noise ratios (SNRs) of 82.2 ± 15.3 and 15.1 ± 7.1 (mean?±?standard deviation) were achieved for imaging of tumour tissue sodium concentration (TSC) and intracellular weighted sodium concentration (IWS) respectively. Tumour TSC and IWS concentrations were: 56.8?±?19.1?mM and 30.8?±?9.2?mM respectively and skeletal muscle TSC and IWS concentrations were 33.2?±?16.3?mM and 20.5?±?9.9?mM respectively. There were significant sodium concentration differences between cancer and skeletal muscle, Wilcoxon signed-rank test, P?

SUBMITTER: Deen SS 

PROVIDER: S-EPMC6477161 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature