Repeatability and reproducibility of longitudinal relaxation rate in 12 small-animal MRI systems.

ABSTRACT:

Background

Many translational MR biomarkers derive from measurements of the water proton longitudinal relaxation rate R₁, but evidence for between-site reproducibility of R₁ in small-animal MRI is lacking.

Objective

To assess R₁ repeatability and multi-site reproducibility in phantoms for preclinical MRI.

Methods

R₁ was measured by saturation recovery in 2% agarose phantoms with five nickel chloride concentrations in 12 magnets at 5 field strengths in 11 centres on two different occasions within 1-13 days. R₁ was analysed in three different regions of interest, giving 360 measurements in total. Root-mean-square repeatability and reproducibility coefficients of variation (CoV) were calculated. Propagation of reprod

SUBMITTER: Waterton JC 

PROVIDER: S-EPMC6477178 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature