Disentangling Microbial Mediators of Malnutrition: Modeling Environmental Enteric Dysfunction.

ABSTRACT: Environmental enteric dysfunction (EED) (also referred to as environmental enteropathy) is a subclinical chronic intestinal disorder that is an emerging contributor to early childhood malnutrition. EED is common in resource-limited settings, and is postulated to consist of small intestinal injury, dysfunctional nutrient absorption, and chronic inflammation that results in impaired early child growth attainment. Although there is emerging interest in the hypothetical potential for chemical toxins in the environmental exposome to contribute to EED, the propensity of published data, and hence the focus of this review, implicates a critical role of environmental microbes. Early childhood malnutrition and EED are most prevalent in resource-limited settings where food is limited, and inadequate

SUBMITTER: Bartelt LA 

PROVIDER: S-EPMC6477186 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature