IMMU-10. CENTRAL NERVOUS SYSTEM NEUROBLASTOMA METASTASES PSEUDOPROGRESSION FOLLOWING INTRAVENTRICULAR ANTI-B7H3 RADIOIMMUNOTHERAPY

ABSTRACT: Abstract BACKGROUND: While immunotherapy has revolutionized the treatment for several solid tumors, pseudoprogression, radiographically defined as the initial increase in tumor volume followed by tumor shrinkage, is less clearly defined. This is particularly noteworthy for patients with central nervous system metastases, commonly seen in patients with advanced melanoma or non-small cell lung cancer treated with PD-1 or CTLA-4 inhibitors. B7-H3 (CD276) is a transmembrane protein belonging to the B7 family of costimulatory molecules. 1 Several solid tumors overexpress B7-H3, and expression appears to be closely associated with immune escape, tumor cell invasion and metastases. The incidence of pseudoprogression after B7-H3 therapy is unknown. METHOD: A 4 year old girl with central nervous sy

SUBMITTER: Kramer K 

PROVIDER: S-EPMC6477354 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature