Prenatal methylmercury exposure and genetic predisposition to cognitive deficit at age 8 years.

ABSTRACT:

Background

Cognitive consequences at school age associated with prenatal methylmercury (MeHg) exposure may need to take into account nutritional and sociodemographic cofactors as well as relevant genetic polymorphisms.

Methods

A subsample (n = 1,311) of the Avon Longitudinal Study of Parents and Children (Bristol, UK) was selected, and mercury (Hg) concentrations were measured in freeze-dried umbilical cord tissue as a measure of MeHg exposure. A total of 1135 children had available data on 247 single-nucleotide polymorphisms (SNPs) within relevant genes, as well as the Wechsler Intelligence Scale for Children Intelligence Quotient (IQ) scores at age 8 years. Multivariate regression models were used to assess the associations between MeHg exposure and IQ and to determine pos

SUBMITTER: Julvez J 

PROVIDER: S-EPMC6477679 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature