A Comparative Study of Carvedilol Versus Metoprolol Initiation and 1-Year Mortality Among Individuals Receiving Maintenance Hemodialysis.

ABSTRACT:

Background

Carvedilol and metoprolol are the β-blockers most commonly prescribed to US hemodialysis patients, accounting for ∼80% of β-blocker prescriptions. Despite well-established pharmacologic and pharmacokinetic differences between the 2 medications, little is known about their relative safety and efficacy in the hemodialysis population.

Study design

A retrospective cohort study using a new-user design.

Setting & participants

Medicare-enrolled hemodialysis patients treated at a large US dialysis organization who initiated carvedilol or metoprolol therapy from January 1, 2007, through December 30, 2012.

Predictor

Carvedilol versus metoprolol initiation.

Outcomes

All-cause mortality, cardiovascular mortality, and intradialytic hypotension (systolic bl

SUBMITTER: Assimon MM 

PROVIDER: S-EPMC6477681 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature