Split tolerance permits safe Ad5-GUCY2C-PADRE vaccine-induced T-cell responses in colon cancer patients.

ABSTRACT:

Background

The colorectal cancer antigen GUCY2C exhibits unique split tolerance, evoking antigen-specific CD8⁺, but not CD4⁺, T-cell responses that deliver anti-tumor immunity without autoimmunity in mice. Here, the cancer vaccine Ad5-GUCY2C-PADRE was evaluated in a first-in-man phase I clinical study of patients with early-stage colorectal cancer to assess its safety and immunological efficacy.

Methods

Ten patients with surgically-resected stage I or stage II (pN0) colon cancer received a single intramuscular injection of 10¹¹ viral particles (vp) of Ad5-GUCY2C-PADRE. Safety assessment and immunomonitoring were carried out for 6 months following immunization. This trial employed continual monitoring of both efficacy and toxicity of subjects

SUBMITTER: Snook AE 

PROVIDER: S-EPMC6477737 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature