Icariin attenuates neuroinflammation and exerts dopamine neuroprotection via an Nrf2-dependent manner.

ABSTRACT:

Background

Oxidative stress and neuroinflammation are considered the major central events in the process of Parkinson's disease (PD). Nrf2 is a key regulator of endogenous defense systems. New finds have contacted activation of Nrf2 signaling with anti-inflammatory activities. Therefore, the outstanding inhibition of neuroinflammation or potent Nrf2 signaling activation holds a promising strategy for PD treatment. Icariin (ICA), a natural compound derived from Herba Epimedii, presents a number of pharmacological properties, including anti-oxidation, anti-aging and anti-inflammatory actions. Recent studies have confirmed ICA exerted neuroprotection against neurodegenerative disorders. However, the underlying mechanisms were not fully elucidated.

Methods

In the present study,

SUBMITTER: Zhang B 

PROVIDER: S-EPMC6477740 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature