Low skeletal muscle mass is associated with the risk of all-cause mortality in patients with type 2 diabetes mellitus.

ABSTRACT:

Background

Patients with type 2 diabetes mellitus (T2DM) have an increased risk of muscle mass reduction. However, the association between muscle mass and mortality in T2DM remains unknown.

Methods

This was a historical cohort study with the endpoint of all-cause mortality. This study included 163 Japanese men and 141 postmenopausal women with T2DM whose body compositions were evaluated using dual-energy X-ray absorptiometry. Low muscle mass was defined as a skeletal muscle mass index (SMI) of <7.0 kg/m² for men and <5.4 kg/m² for women.

Results

During the 6-year follow-up period, 32 men and 14 women died. In a Cox regression analysis adjusted for age, T2DM duration, glycated hemoglobin, serum creatinine, fasting C-peptide, body mass index, and l

SUBMITTER: Miyake H 

PROVIDER: S-EPMC6477760 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature