Are BMI and inflammatory markers independently associated with physical fatigability in old age?

ABSTRACT:

Background

Obesity and chronic low-grade inflammation have both been implicated in the onset of physical fatigue. However, few studies have investigated the independence of these associations in older community-dwelling populations. We therefore aimed to investigate the associations of body mass index (BMI) and inflammatory markers at age 60-64 with perceived physical fatigability at age 68 and to assess whether any such associations were independent of each other and potential confounding factors. A secondary aim was to investigate whether any association with BMI extended back into earlier adulthood.

Methods

Participants of the MRC National Survey of Health and Development (N = 1580) had BMI and levels of interleukin-6 (IL-6) and C-reactive protein (CRP) measured during cl

SUBMITTER: Cooper R 

PROVIDER: S-EPMC6477893 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature