Liver injury is associated with mortality in sickle cell disease.

ABSTRACT:

Background

Increased life expectancy in sickle cell disease (SCD) has resulted in greater recognition of the consequences of repeated intravascular vaso-occlusion and chronic haemolysis to multiple organ systems.

Aim

To report the long-term consequences of liver dysfunction in SCD.

Methods

A cohort of SCD patients was prospectively evaluated at the National Institutes of Health (NIH) Clinical Center. The association of mortality with liver enzymes, parameters of liver synthetic function and iron overload was evaluated using Cox regression.

Results

Exactly, 247 SCD patients were followed up for 30 months of whom 22 (9%) died. After controlling for predictors, increased direct bilirubin (DB), ferritin, alkaline phosphatase and decreased albumin were independently

SUBMITTER: Feld JJ 

PROVIDER: S-EPMC6478018 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature