Schizophrenia and Corollary Discharge: A Neuroscientific Overview and Translational Implications.

ABSTRACT: Corollary discharge mechanism refers to the suppression of sensory consequences of self-generated actions; a process that serves to distinguish between self and non-self based on discrimination of origination of action. It explains, say for example, why we cannot tickle ourselves. This review discusses how corollary discharge model is an essential neural integration mechanism central to the motor functioning of animal kingdom. In this article, research conducted in the field of corollary discharge has been reviewed to understand the neuroanatomical and neurophysiological basis of corollary discharge and gain insight into the biochemical basis of its dysfunction. This review article also explores the role of corollary discharge and its dysfunction in the presentation of symptoms of schizoph

SUBMITTER: Parlikar R 

PROVIDER: S-EPMC6478093 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature