Host-response-based gene signatures for tuberculosis diagnosis: A systematic comparison of 16 signatures.

ABSTRACT:

Background

The World Health Organization (WHO) and Foundation for Innovative New Diagnostics (FIND) have published target product profiles (TPPs) calling for non-sputum-based diagnostic tests for the diagnosis of active tuberculosis (ATB) disease and for predicting the progression from latent tuberculosis infection (LTBI) to ATB. A large number of host-derived blood-based gene-expression biomarkers for diagnosis of patients with ATB have been proposed to date, but none have been implemented in clinical settings. The focus of this study is to directly compare published gene signatures for diagnosis of patients with ATB across a large, diverse list of publicly available gene expression datasets, and evaluate their performance against the WHO/FIND TPPs.

Methods and findings

We

SUBMITTER: Warsinske H 

PROVIDER: S-EPMC6478271 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature