T-cell derived acetylcholine aids host defenses during enteric bacterial infection with Citrobacter rodentium.

ABSTRACT: The regulation of mucosal immune function is critical to host protection from enteric pathogens but is incompletely understood. The nervous system and the neurotransmitter acetylcholine play an integral part in host defense against enteric bacterial pathogens. Here we report that acetylcholine producing-T-cells, as a non-neuronal source of ACh, were recruited to the colon during infection with the mouse pathogen Citrobacter rodentium. These ChAT+ T-cells did not exclusively belong to one Th subset and were able to produce IFNγ, IL-17A and IL-22. To interrogate the possible protective effect of acetylcholine released from these cells during enteric infection, T-cells were rendered deficient in their ability to produce acetylcholine through a conditional gene knockout approach. Significantly

SUBMITTER: Ramirez VT 

PROVIDER: S-EPMC6478367 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature