Are Environmental Factors for Atopic Eczema in ISAAC Phase Three due to Reverse Causation?

ABSTRACT: Some previously described environmental associations for atopic eczema may be due to reverse causation. We explored the role of reverse causation by comparing individual- and school-level results for multiple atopic eczema risk factors. The International Study of Asthma and Allergies in Childhood (i.e, ISAAC) Phase Three surveyed children in schools (the sampling unit) regarding atopic eczema symptoms and potential risk factors. We assessed the effect of these risk factors on atopic eczema symptoms using mixed-effect logistic regression models, first with individual-level exposure data and second with school-level exposure prevalence. Overall, 546,348 children from 53 countries were included. At ages 6-7 years, the strongest individual-level associations were with current paracetamol use (

SUBMITTER: Rutter CE 

PROVIDER: S-EPMC6478380 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature