Cell type-specific immune phenotypes predict loss of insulin secretion in new-onset type 1 diabetes.

ABSTRACT: The rate of decline in insulin secretion after diagnosis with type 1 diabetes (T1D) varies substantially among individuals and with age at diagnosis, but the mechanism(s) behind this heterogeneity are not well understood. We investigated the loss of pancreatic β cell function in new-onset T1D subjects using unbiased whole blood RNA-seq and verified key findings by targeted cell count measurements. We found that patients who lost insulin secretion more rapidly had immune phenotypes ("immunotypes") characterized by higher levels of B cells and lower levels of neutrophils, especially neutrophils expressing primary granule genes. The B cell and neutrophil immunotypes showed strong age dependence, with B cell levels in particular predicting rate of progression in young subjects only. This age r

SUBMITTER: Dufort MJ 

PROVIDER: S-EPMC6478408 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature