Negligible Role for Deletion Mediated by cDC1 in CD8⁺ T Cell Tolerance.

ABSTRACT: Deletion of CD8⁺ T cells by dendritic cells (DCs) is recognized as a critical mechanism of immune tolerance to self-antigens. Although DC-mediated peripheral deletion of autoreactive CD8⁺ T cells has been demonstrated using T cells reactive to model Ags, its role in shaping the naturally occurring polyclonal CD8⁺ T cell repertoire has not been defined. Using Batf3^-/- mice lacking cross-presenting CD8α⁺ and CD103⁺ DCs (also known as type 1 conventional [cDC1]), we demonstrate that peripheral deletion of CD8⁺ T cells reactive to a model tissue Ag is dependent on cDC1. However, endogenous CD8⁺ T cells from the periphery of Batf3^-/- mice do not exhibit heightened self-reactivity, an

SUBMITTER: MacNabb BW 

PROVIDER: S-EPMC6478510 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature