TCR Affinity Biases Th Cell Differentiation by Regulating CD25, Eef1e1, and Gbp2.

ABSTRACT: Naive CD4⁺ T lymphocytes differentiate into various Th cell subsets following TCR binding to microbial peptide:MHC class II (p:MHCII) complexes on dendritic cells (DCs). The affinity of the TCR interaction with p:MHCII plays a role in Th differentiation by mechanisms that are not completely understood. We found that low-affinity TCRs biased mouse naive T cells to become T follicular helper (Tfh) cells, whereas higher-affinity TCRs promoted the formation of Th1 or Th17 cells. We explored the basis for this phenomenon by focusing on IL-2R signaling, which is known to promote Th1 and suppress Tfh cell differentiation. SIRP⍺⁺ DCs produce abundant p:MHCII complexes and consume IL-2, whereas XCR1⁺ DCs weakly produce p:MHCII but do not consume IL-2. We found no ev

SUBMITTER: Kotov DI 

PROVIDER: S-EPMC6478541 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature