Genome-wide significant regions in 43 Utah high-risk families implicate multiple genes involved in risk for completed suicide.

ABSTRACT: Suicide is the 10th leading cause of death in the United States. Although environment has undeniable impact, evidence suggests that genetic factors play a significant role in completed suicide. We linked a resource of ~ 4500 DNA samples from completed suicides obtained from the Utah Medical Examiner to genealogical records and medical records data available on over eight million individuals. This linking has resulted in the identification of high-risk extended families (7-9 generations) with significant familial risk of completed suicide. Familial aggregation across distant relatives minimizes effects of shared environment, provides more genetically homogeneous risk groups, and magnifies genetic risks through familial repetition. We analyzed Illumina PsychArray genotypes from suicide cases

SUBMITTER: Coon H 

PROVIDER: S-EPMC6478563 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature