GHS-R1a Deficiency Alleviates Depression-Related Behaviors After Chronic Social Defeat Stress.

ABSTRACT: Ghrelin is an important orexigenic hormone that regulates feeding, metabolism and glucose homeostasis in human and rodents. Ghrelin functions by binding to its receptor, the growth hormone secretagogue receptor 1a (GHS-R1a), which is widely expressed inside and outside of the brain. Recent studies suggested that acyl-ghrelin, the active form of ghrelin, is a persistent biomarker for chronic stress exposure. However, how ghrelin/GHS-R1a signaling contributes to stress responses and mood regulation remains uncertain. In this study, we applied the chronic social defeat stress (CSDS) paradigm to both GHS-R1a knock-out (Ghsr ^-/-) mice and littermate control (Ghsr ^+/+) mice, and then measured their depression- and anxiety-related behaviors. We found tha

SUBMITTER: Guo L 

PROVIDER: S-EPMC6478702 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature