Dataset Information

Egocentrically-stable discriminative stimulus-based spatial navigation in mice: implementation and comparison with allocentric cues.

ABSTRACT: Animals are capable of using visual cues to find the correct route during navigation. These visual cues, which contain spatial information on the direction towards the goal point, are perceived either allocentrically or egocentrically. In this study, we examined how navigating with these two types of visual cues affects the learning processes of rodents. To present egocentrically-stable spatial cues, we devised a head-mounted device that provided discriminative orientation cues that indicated the correct choice at a fork within a double Y-maze. For allocentrically-stable spatial cues, LEDs serving as external route-mark cues were attached to the walls of the double Y-maze and illuminated to indicate the correct pathway. To rule out the possibility of the mice using extra-maze cues, we rotated the entire maze and used different start and goal sites for every trial. Our results revealed that mice using egocentric cues and external route-mark cues both showed a sigmoidal learning process for spatial navigation and that external route mark-based learning, surprisingly, learned faster than egocentric stimulus-based learning in egocentric space.

SUBMITTER: Chun J

PROVIDER: S-EPMC6478847 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Egocentrically-stable discriminative stimulus-based spatial navigation in mice: implementation and comparison with allocentric cues.

Chun Jinsung J Kim Youngsoo Y Choi Jin Woo JW Kim Daesoo D Jo Sungho S

Scientific reports 20190423 1

Animals are capable of using visual cues to find the correct route during navigation. These visual cues, which contain spatial information on the direction towards the goal point, are perceived either allocentrically or egocentrically. In this study, we examined how navigating with these two types of visual cues affects the learning processes of rodents. To present egocentrically-stable spatial cues, we devised a head-mounted device that provided discriminative orientation cues that indicated th ...[more]

PMID: 31015510

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Project description:Positive modulation of GABA(A) and antagonism of N-methyl-D-aspartate receptors mediate the discriminative stimulus effects of ethanol. Endogenous neuroactive steroids produce effects similar to ethanol, suggesting that these steroids may modulate ethanol addiction. The four isomers of the functional esters at C-3 of the 3-hydroxy metabolites of 4-pregnene-3,20-dione (progesterone) [allopregnanolone (3alpha,5alpha-P), pregnanolone (3alpha,5beta-P), epiallopregnanolone (3beta,5alpha-P), and epipregnanolone (3beta,5beta-P)], a synthetic analog of steroids modified by endogenous sulfation [pregnanolone hemisuccinate (3alpha,5beta-P HS)], and a structurally similar, adrenally derived steroid [3alpha-hydroxy-5-androstan-17-one (3alpha,5alpha-A, androsterone)] were assessed for ethanol-like discriminative stimulus effects at 30 or 60 min after administration in male (n = 9) and female (n = 8) cynomolgus monkeys (Macaca fascicularis) trained to discriminate 1.0 or 2.0 g/kg ethanol (i.g.) with a 30-min pretreatment interval. The 3alpha-hydroxysteroids completely substituted for ethanol (80% of cases), whereas the 3beta-hydroxysteroids and 3alpha,5beta-P HS rarely substituted for ethanol (6% of cases). There were no sex differences. Compared with monkeys trained to discriminate 2.0 g/kg ethanol, 3alpha,5beta-P and 3alpha,5alpha-A substituted more potently in monkeys trained to discriminate 1.0 g/kg ethanol. Compared with the 5beta-reduced isomer (3alpha,5beta-P), the 5alpha isomer of pregnanolone (3alpha,5alpha-P) substituted for ethanol with 3 to 40-fold greater potency but was least efficacious in female monkeys trained to discriminate 2.0 g/kg ethanol. The data suggest that the discriminative stimulus effects of lower doses (1.0 g/kg) of ethanol are mediated to a greater extent by 3alpha,5beta-P- and 3alpha,5alpha-A-sensitive receptors compared with higher doses (2.0 g/kg). Furthermore, the discriminative stimulus effects of ethanol appear to be mediated by activity at binding sites that are particularly sensitive to 3alpha,5alpha-P.

Dataset Information

Egocentrically-stable discriminative stimulus-based spatial navigation in mice: implementation and comparison with allocentric cues.

Publications

Egocentrically-stable discriminative stimulus-based spatial navigation in mice: implementation and comparison with allocentric cues.

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