Cerebellar, limbic, and midbrain volume alterations in sudden unexpected death in epilepsy.

ABSTRACT:

Objective

The processes underlying sudden unexpected death in epilepsy (SUDEP) remain elusive, but centrally mediated cardiovascular or respiratory collapse is suspected. Volume changes in brain areas mediating recovery from extreme cardiorespiratory challenges may indicate failure mechanisms and allow prospective identification of SUDEP risk.

Methods

We retrospectively imaged SUDEP cases (n = 25), patients comparable for age, sex, epilepsy syndrome, localization, and disease duration who were high-risk (n = 25) or low-risk (n = 23), and age- and sex-matched healthy controls (n = 25) with identical high-resolution T1-weighted scans. Regional gray matter volume, determined by voxel-based morphometry, and segmentation-derived structure sizes were compared across groups, contro

SUBMITTER: Allen LA 

PROVIDER: S-EPMC6479118 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature