Chd2 Is Necessary for Neural Circuit Development and Long-Term Memory.

ABSTRACT: Considerable evidence suggests loss-of-function mutations in the chromatin remodeler CHD2 contribute to a broad spectrum of human neurodevelopmental disorders. However, it is unknown how CHD2 mutations lead to impaired brain function. Here we report mice with heterozygous mutations in Chd2 exhibit deficits in neuron proliferation and a shift in neuronal excitability that included divergent changes in excitatory and inhibitory synaptic function. Further in vivo experiments show that Chd2^+/- mice displayed aberrant cortical rhythmogenesis and severe deficits in long-term memory, consistent with phenotypes observed in humans. We identified broad, age-dependent transcriptional changes in Chd2^+/- mice, including alterations in neurogenesis, synaptic transmission, and disea

SUBMITTER: Kim YJ 

PROVIDER: S-EPMC6479120 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature