Interrelations of Sphingolipid and Lysophosphatidate Signaling with Immune System in Ovarian Cancer.

ABSTRACT: The sphingolipid and lysophosphatidate regulatory networks impact diverse mechanisms attributed to cancer cells and the tumor immune microenvironment. Deciphering the complexity demands implementation of a holistic approach combined with higher-resolution techniques. We implemented a multi-modular integrative approach consolidating the latest accomplishments in gene expression profiling, prognostic/predictive modeling, next generation digital pathology, and systems biology for epithelial ovarian cancer. We assessed patient-specific transcriptional profiles using the sphingolipid/lysophosphatidate/immune-associated signature. This revealed novel sphingolipid/lysophosphatidate-immune gene-gene associations and distinguished tumor subtypes with immune high/low context. These were characterize

SUBMITTER: Meshcheryakova A 

PROVIDER: S-EPMC6479272 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature