Septic patients in the intensive care unit present different nasal microbiotas.

ABSTRACT:

Aim

The primary objective of this study was to evaluate correlations among mortality, intensive care unit (ICU) length of stay and airway microbiotas in septic patients.

Materials & methods

A deep-sequencing analysis of the 16S rRNA gene V4 region was performed.

Results

The nasal microbiota in septic patients was dominated by three nasal bacterial types (Corynebacterium, Staphylococcus and Acinetobacter). The Acinetobacter type was associated with the lowest diversity and longest length of stay (median: 9 days), and the Corynebacterium type was associated with the shortest length of stay. We found that the Acinetobacter type in the >9-day group was associated with the highest mortality (33%).

Conclusion

Septic patients have three nasal microbiota types, and the

SUBMITTER: Tan XL 

PROVIDER: S-EPMC6479279 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature