Mechanistic Insights in NeuroD Potentiation of Mineralocorticoid Receptor Signaling.

ABSTRACT: Mineralocorticoid receptor (MR)-mediated signaling in the brain has been suggested as a protective factor in the development of psychopathology, in particular mood disorders. We recently identified genomic loci at which either MR or the closely related glucocorticoid receptor (GR) binds selectively, and found members of the NeuroD transcription factor family to be specifically associated with MR-bound DNA in the rat hippocampus. We show here using forebrain-specific MR knockout mice that GR binding to MR/GR joint target loci is not affected in any major way in the absence of MR. Neurod2 binding was also independent of MR binding. Moreover, functional comparison with MyoD family members indicates that it is the chromatin remodeling aspect of NeuroD, rather than its direct stimulation of tra

SUBMITTER: van Weert LTCM 

PROVIDER: S-EPMC6479562 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature